Based on the Thelansis market insight report on Alport Syndrome (AS) which provides a clear understanding of disease area background, epidemiology, current and future competitions, the country-specific standard of care, and the complete market forecast for 2020 to 2030.
The annual incidence/ diagnosed cases of Alport Syndrome varies between 130,000 to 154,000 in the year 2020. ~80?ses had typical glomerular basement membrane (GBM) changes of AS, ~10% patients initially had pathology features of diffuse thinning of the GBM only, 14% patients showed pathology of focal segmental glomerulosclerosis (FSGS)
Comprehensive insight on patient segmentation based on Age, Sex, types (X-linked, Autosomal, and Digenic ), stages (Stage – 0, I, II, III, IV, V), Renal Manifestation Frequency (hematuria, proteinuria, end-stage renal disease, transplantation), Extrarenal Manifestation (sensorineural hearing loss, Ocular Lesions and others), Inheritance & Mutation (XLAS; COL4A5, ARAS; COL4A3, & COL4A4, ADAS; COL4A3 OR COL4A4) has been provided into the epidemiology (Incidence and Prevalence) section of the Alport Syndrome(AS) and its treatment in the 8 MM countries, covering the United States, EU5 (Germany, Spain, France, Italy, UK), Japan, and China
Considering Alport syndrome is an excellent model of CKD with proteinuria and fibrosis, orphan drug designation with premium pricing benefits, number of patients to be treated will be substantial and finally s no approved treatment several drug candidates are in Phase II and II/ III stages of development by various companies. Key assets among these are Bardoxolone Methyl; Reata Pharmaceuticals, RG-012; Sanofi/ Regulus/ Genzyme, BMP-7; Ember Therapeutics, VAR300; ZyVersa Therapeutics. The launch of key assets will positively impact the overall market till 2030. While there is a lot of competitive activity going on in the pipeline for AS, companies like Reata Pharmaceuticals; Bardoxolone Methyl holds Orphan drug designation by US FDA and EMA. Patients treated with bardoxolone experienced a significant increase in eGFR of 7.8 mL/min/1.73 m2 (n=18; p=0.003) at Week 12 compared to baseline and to be found significantly improves kidney functions and well-tolerated among the different cohort of treatments.
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