The overall prevalence of HBV/HDV co-infection was determined to be 8%, with cirrhosis present in 73% of the co-infected, 80% of the tri-infected (HDV/HBV along with hepatitis C infection), but only 22% of HBV mono-infection.
Comprehensive insight on patient segmentation based on Age group, Sex, Isolates (Genotype – I, II & III), co-infection with HDV and HBV of a susceptible, anti-HBs-negative individual, and HDV superinfection of a chronic HBV carrier, Type of settings (Acute & Chronic) has been provided into the epidemiology (Incidence and Prevalence) section of the HDV and its treatment in the 8 MM coun-tries, covering the United States, EU5 (Germany, Spain, France, Italy, UK), Japan, and China
Despite interferon-a (IFNa) & Peg-iFn-? usage, the primary concern is the prevention of the progression of the disease and its lateral damages such as cirrhosis, liver failure, and carcinoma. Currently companies like Roche; Pegasys, Replicor Inc.; REP 2139-Ca + Pegasys, MYR Pharma; Myrcludex B, Eiger BioPharmaceuti-cals; Lonafarnib, Eiger BioPharmaceuticals; Pegylated interferon lambda 1a. The market is expected to witness rapid growth with the launch of designated emerging therapies, such as Myrcludex B; MYR Pharma (Orphan designation), Lonafarnib; Eiger BioPharmaceuti-cals (Fast Track & Orphan designation). Myrcludex B showed a strong effect on HDV RNA serum levels and induced ALT normalization under monotherapy. Among the key assets, some of the companies like Merck Sharp & Dohme Corp., Gilead Sciences, Arrowhead Pharmaceuticals, and Boehringer Ingelheim are in the race to build their assets within the market space
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